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Letter of Intent Due Date s required due by 5 p. Scientific research into complex coastal systems and the interplay with coastal hazards is vital for predicting, responding to and mitigating threats in these regions. Understanding the risks associated with coastal hazards requires a holistic Earth Systems approach that integrates improved understanding of and, where possible, predictions about natural, social, and technological processes with efforts to increase the resilience of coastal systems.

The Coastlines and People program supports diverse, innovative, multi-institution awards that are focused on critically important coastlines and people research that is integrated with broadening participation goals.

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The objective of this solicitation is to support Coastal Research Hubs, structured using a convergent science approach, at the nexus between coastal sustainability, human dimensions, and coastal processes to transform understanding of interactions among natural, human-built, and social systems in coastal, populated environments. Please note that the following information is current at the time of publishing. See program website for any updates to the points of contact.

CoPe Working Group, telephone:email: nsfcope nsf. Due to the potential scope and complexity of the Large-scale hubs, the awards may be continuing grants or cooperative agreements.

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Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education including through use of subawards and consultant arrangementsthe proposer must explain the benefit s to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus.

An individual may be listed as a PI or co-PI on no more than one Hub proposal submitted in response to this solicitation. Proposals exceeding the limit for any person will be returned without review in the reverse order received.

There is no limit on the number of proposals on which an investigator may be listed as Lead of a Subaward or as Other Senior Personnel. National Science Board approved criteria. Additional merit review criteria apply. Please see the full text of this solicitation for further information. Coasts are paramount to our nation's economic prosperity, sustainability and national security.

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Critically, 1, military sites across the globe depend on the stability ofkilometers 95, miles of coastline Center for Climate and Security, Coastal counties in the lower 48 states have a population density that is six times greater than corresponding inland counties and is growing rapidly National Ocean Service, According to the U.

Census, The Great Lakes hold environmental, cultural, and economic value for both the region and the nation.

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Often referred to as the "Third Coast," the five Great Lakes possess 95 percent of the country's surface fresh water supply. The Great Lakes Basin includes counties and 13 major urban areas; about Environmental phenomena of terrestrial, oceanic, and atmospheric origin are constantly changing coastal landscapes and affect human habitats and infrastructure.

Sea-level rise will continue to cause serious economic, social and environmental impacts to coastlines around the globe. Research has shown that all coastal cities will see some impacts of global sea level rise Larour, Climate change is leading to warming seas, causing about half the eustatic sea level rise and impacting precipitation patterns which alter coastal hydrology and ecosystems. Devastating earthquakes, tsunamis, and landslides occur at subduction zones, five of which exist along coastlines in the U.

Inthe most powerful earthquake in U. A great deal of public critical infrastructure, such as housing, transportation, water supply, and electricity generation and distribution, is vulnerable to extreme weather events, sea-level rise, coastal flooding, algal blooms and tectonic hazards. Significant population growth in coastal regions increases risk exposure to these coastal hazards. This motivates an investment in interdisciplinary, convergent research across many disciplines including biology, engineering, geoscience, and the social and behavioral science.

Convergent research is driven by specific challenge or opportunity. It entails integrating knowledge, methods, and expertise from different disciplines to form novel frameworks to catalyze scientific discovery and innovation. Therefore, critical sectors of the global coastal economy, e.Save Hide Contact Print Share. Save Hide Share. What's Your Home Worth? General form error. This error applies to the full form. For a complimentary comparative market analysis, please contact us so we can discuss your home's value.

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Do you have questions about finding other Single Family real estate for sale in McGregor? You can browse all McGregor real estate or contact a Coldwell Banker agent to request more information. A new affordable option from Home Partners of America. They buy the home, you lease it for years with a right to purchase. Learn more about the program. View more details about this property.

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Your Email.Save Hide Contact Print Share. Save Hide Contact Share. Quickly Find Out More. General form error. This error applies to the full form. Full Name. Email Address. Mobile Phone Number. See this property in person. Any Morning Afternoon Evening. Comment optional. Yes, I would like more information from Coldwell Banker.

By clicking SUBMIT, I agree a Coldwell Banker Agent may contact me by phone or text message including by automated means about real estate services, and that I can access real estate services without providing my phone number. See This Home. Contact Me. Phone Number optional. Contact Us. Keith Hittner, Jr. Email Me.

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A new affordable option from Home Partners of America. They buy the home, you lease it for years with a right to purchase. Learn more about the program. View more details about this property. Your Email.You will be responsible for any damage to the rental property caused by you or your party during your stay.

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Free cancellation up to 60 days before check-in. Wally Shoczolek Ask owner a question. Property View all Hilton Head Island properties. Property overview. House sq.

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Sleeps: 10 Bedrooms: 4 Bathrooms: 3 Min Stay: 7 nights. House, 4 Bedrooms, 3 Baths, Sleeps Bedrooms: 4. Sleeps: Bedroom 3. Amenities Featured No Smoking. Bathrooms Bathrooms: 3. General Telephone.

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Parking Available for 4 cars which is strictly enforced by security. Tickets will be issued for violations. Wireless Internet Available throughout the house.

Kitchen Dishwasher. Stove Electric. Kitchen Large spacious kitchen that is open to the dining and living room areas. Dining Seating for 10 people. Entertainment Television Televisions in each room as well as kitchen. Suitability wheelchair inaccessible. Onsite Services Housekeeper Included. Notes No Pets. No refund if you cancel less than 60 days before check-in.

Learn more about our cancellation policies.Redfin Estimate based on recent home sales. Our gears are turning, but we don't have enough information about your home to generate an accurate estimate at this time. Learn more about the Rental Estimate.

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The Isle at Mission Bay is a hidden treasure of custom homes in a gated community. No other home in this community has the floor plan as this one. The wide view from the living room, family room and master bedroom to the private backyard with a salt pool will call your name every time your eyes are caught looking at it.

Formal dinning room, office or game room. Two luxury fire places, 5 skylights and 4 double french doors to the pool area. Irrigation sprinklers from well. This house calls for someone that appreciates a ranch style with a modern touch. Some upgrades to this home have been done such as new interior paint, hardwood floor in the bedrooms, a 3. Don't forget to check the beautiful clubhouse.

United States. California DRE If you are using a screen reader, or having trouble reading this website, please call Redfin Customer Support for help at Redfin Estimate. Built: Public Facts. Listing Details. Similar Homes. Street View.

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HOA dues Add. Rental Estimate for Sausalito Dr Our gears are turning, but we don't have enough information about your home to generate an accurate estimate at this time. Edit Home Facts to make sure we've got the right info. Market trends for Palm Beach County. Rental estimate based on recent rentals. Continue reading. Redfin last checked: 12 minutes ago Last updated Feb 22, Status Closed. Year Built Save Hide Contact Print Share. Save Hide Contact Share.

Quickly Find Out More. General form error. This error applies to the full form. Full Name. Email Address. Mobile Phone Number. See this property in person. Any Morning Afternoon Evening. Comment optional. Yes, I would like more information from Coldwell Banker.

By clicking SUBMIT, I agree a Coldwell Banker Agent may contact me by phone or text message including by automated means about real estate services, and that I can access real estate services without providing my phone number.

See This Home. Contact Me. Phone Number optional. Contact Us. Keith Hittner, Jr. Email Me. Gina Enderlein.

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Get Pre-Approved. Want to learn more about Dublin Drive 53?

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Do you have questions about finding other Townhouse real estate for sale in Farmington? You can browse all Farmington real estate or contact a Coldwell Banker agent to request more information. A new affordable option from Home Partners of America. They buy the home, you lease it for years with a right to purchase.

Learn more about the program. View more details about this property.

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Your Email. Recipient's Name. Recipient's Email.Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

Sphingosine Kinase SphK catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosinephosphate S1P. S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation.

SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors.

SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY For Research Use Only.

Not for use in diagnostic procedures. Not for resale without express authorization. Entrez Gene ID: Human Molecular Function: DNA binding protein endodeoxyribonuclease nuclease. Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use. Search Thermo Fisher Scientific. Search All. View all 9 Dicer antibodies. Datasheet Created with sketchtool. Create Citation Created with sketchtool.

Create Citation. Tech Support Created with sketchtool. Tech Support. Click to Copy. Product Details. Immunocytochemistry ICC. Immunofluorescence IF. Immunoprecipitation IP. Western Blot WB. View 6 publications 6 publications. Product Specifications. Human, Mouse. Target Information Sphingosine Kinase SphK catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosinephosphate S1P. Function s.

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Process es. It has to be done as per old AB suggested Products section. We're here to help Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

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